St Louis is a city in Missouri. Tobias and Sarah visit this city while going on a road trip. In a far future scenario, it was consumed by the Mississippi River, however that is non cannon and there is no sign that the city will ever meet a demise.
Alternate St. Louis[]
In the Amerigo Empire St. Louis is a major hub for traveling, and a leading city in industry and culture. It may also very well be more of an Alternate Chicago.